The most common symptoms of the disease include jaundice. The liver stops processing bilirubin normally, leading to this condition. Patients may notice yellow discoloration of the skin and whites of the eyes.

The pain may be localized in the right upper abdomen. They can be moderate or intense. Patients often complain of fatigue and weakness. As the disease progresses, patients may lose weight for no apparent reason.

The exact cause of the disease remains unknown, but it is thought to be an autoimmune disease in which the organ’s immune system affects the bile ducts. Genetic factors may also play a role in the development of this disease.

As a result of the autoimmune reaction, the internal flow of the bile ducts is preserved, resulting in scar formation and narrowing of these ducts. This can result in impaired bile outflow, which in turn leads to impaired liver function.

Diagnosis at MDI Clinic

The physician gathers information about the patients’ medical and family history. Evaluates symptoms such as jaundice, abdominal pain, fatigue, and weight loss. By blood tests determine the level of biochemical markers – alkaline phosphatase, bilirubin, aminotransferase (ALT and AST). Check for changes associated with biliary tract pathology.

With ultrasound examination allows visualization of the bile ducts and frequency changes such as or dilation of structural abnormalities. Magnetic resonance examination reveals structural changes and narrowing.

The endoscopic procedure is performed with the injection of a contrast agent to visualize the bile ducts. It can also be used to take biopsies.

Percutaneous transhepatic cholangiography is rarely used, performed by injecting a contrast agent directly into the liver to study the biliary tract.